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Biotin conjugated GLP-1 derivatives DB-GLP-1 and DBP-GLP-1 displayed increased proteolytic stability and retained insulinotropic activity

In March 2024, the Warnings and Precautions section for doctors in the monograph for Ozempic was updated to state that the Use of GLP-1 receptor agonists may be associated with severe gastrointestinal disease and that Events of delayed gastric emptying, dysgeusia and ileus have been reported